Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Imipramine outweigh the risks.
Family and caregivers must closely watch patients who take Imipramine . It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.
Imipramine is used for:
Treating depression. Imipramine HCl is also used in some children to help reduce bedwetting. Imipramine HCl may also be used for other conditions as determined by your doctor.
Imipramine is a tricyclic antidepressant. Imipramine HCl works by increasing the activity of certain chemicals in the brain that help elevate mood.
Do NOT use Imipramine if:
- you are allergic to any ingredient in Imipramine or to similar medicines
- you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days, or if you are taking astemizole, droperidol, or terfenadine
- you are recovering from a recent heart attack
Before using Imipramine :
Some medical conditions may interact with Imipramine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you drink alcohol-containing beverages daily or you have a history of alcohol abuse
- if you take thyroid medicine or you have a history of overactive thyroid, glaucoma, heart problems, kidney or liver problems, diabetes, seizures, the blood disease porphyria, or difficulty urinating
- if you have a history of suicidal thoughts or behavior, bipolar disorder, or any other mental disorders; you are undergoing electroshock therapy; or you are scheduled to have any surgery
Some MEDICINES MAY INTERACT with Imipramine . Tell your health care provider if you are taking any other medicines, especially any of the following:
- Azole antifungals (eg, fluconazole), cimetidine, duloxetine, flecainide, methylphenidate, mibefradil, phenothiazines (eg, chlorpromazine), propafenone, quinidine, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or terbinafine because they may increase the risk of Imipramine 's side effects
- Arsenic, astemizole, droperidol, furazolidone, MAOIs (eg, phenelzine), pimozide, streptogramins (eg, dalfopristin), terfenadine, or tramadol because the risk of high blood pressure, serious heart problems (eg, irregular heartbeat), or seizures may be increased
- Barbiturates (eg, phenobarbital) or phenytoin because they may decrease Imipramine 's effectiveness
- Anticholinergics (eg, benztropine), carbamazepine, or sympathomimetics (eg, phenylephrine) because the risk of their side effects may be increased by Imipramine
- Clonidine, guanethidine, or guanfacine because their effectiveness may be decreased by Imipramine
How to use Imipramine :
Use Imipramine as directed by your doctor. Check the label on Imipramine HCl for exact dosing instructions.
- Imipramine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Imipramine refilled.
- Take Imipramine by mouth with or without food.
- Taking Imipramine at bedtime may help reduce side effects (eg, daytime drowsiness). Discuss this possibility with your doctor.
- It may take 1 to 3 weeks before you notice the effect of Imipramine . Continue to use Imipramine even if you feel well. Do not miss any doses.
- If you miss a dose of Imipramine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you take 1 dose daily at bedtime, do not take the missed dose the next morning.
Important safety information:
- Imipramine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take Imipramine HCl with alcohol or certain medicines. Use Imipramine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to Imipramine HCl.
- Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Imipramine ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Imipramine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Do not become overheated in hot weather or while you are being active; heatstroke may occur.
- Children, teenagers, and young adults who take Imipramine may be at increased risk for suicidal thoughts or actions. Watch all patients who take Imipramine closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
- Imipramine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Imipramine . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Tell your doctor or dentist that you take Imipramine before you receive any medical or dental care, emergency care, or surgery.
- Lab tests, including blood counts, may be performed while you use Imipramine . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Imipramine with caution in the ELDERLY (especially those with cardiac disease); they may be more sensitive to its effects.
- Imipramine should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: It is not known if Imipramine can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Imipramine while you are pregnant. It is not known if Imipramine is found in breast milk. Do not breast-feed while taking Imipramine .
If you suddenly stop taking Imipramine , you may experience WITHDRAWAL symptoms, including headache, nausea, and tiredness.
Possible side effects of Imipramine :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dizziness; drowsiness; dry mouth; excitement; headache; impotence; nausea; nightmares; pupil dilation; sensitivity to sunlight; sweating; tiredness; upset stomach; vomiting; weakness; weight loss or gain.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; changes in sex drive; chest pain; confusion; constipation; fainting; fast, slow, or irregular heartbeat; fever; frequent or difficult urination; hallucinations; impulsive behavior or other unusual changes in behavior; jaw, neck, or muscle spasms; mental or mood changes (eg, increased anxiety, mood swings, agitation, irritability, nervousness, restlessness); panic attacks; ringing in the ears; seizures; severe dizziness or drowsiness; sore throat; stomach pain; suicidal thinking or behavior; swelling of the testicles; tremor; trouble sleeping; trouble walking or keeping your balance; twitching of the face or tongue; uncontrolled movements of arms and legs or stiffness; unusual bleeding or bruising; worsening of depression; yellowing of the skin or eyes.