Noxafil Suspension is used for:

Preventing certain types of fungal infections in patients with severely weakened immune systems. It may be used to treat certain fungal infections of the mouth or throat. It may also be used for other conditions as determined by your doctor.

Noxafil Suspension is an azole antifungal. It works by killing sensitive fungi.

Do NOT use Noxafil Suspension if:

• you are allergic to any ingredient in Noxafil Suspension
• you are taking a 5-HT₁ receptor agonist (eg, eletriptan), certain H₁ antagonists (eg, astemizole, terfenadine), cisapride, conivaptan, an ergot alkaloid (eg, ergotamine), erythromycin, halofantrine, pimozide, a quinazoline (eg, alfuzosin), quinidine, or sirolimus

Before using Noxafil Suspension:

Some medical conditions may interact with Noxafil Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you are allergic to other azole antifungals (eg, itraconazole)
• if you have a history of liver, kidney, or heart problems (eg, irregular heartbeat, abnormal heart function tests)
• if you have abnormal blood electrolyte (eg, potassium, magnesium, calcium) levels
• if you have severe diarrhea or vomiting

Some MEDICINES MAY INTERACT with Noxafil Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amiodarone, certain H₁ antagonists (eg, astemizole, terfenadine), cisapride, dofetilide, erythromycin, halofantrine, levomethadyl, pimozide, or quinidine because the risk of severe heart effects, including irregular heartbeat, may be increased
• HMG-CoA reductase inhibitors (eg, simvastatin) because the risk of severe muscle problems may be increased
• Cimetidine or efavirenz because it may decrease Noxafil Suspension's effectiveness
• Phenytoin or rifabutin because the risk of their side effects may be increased by Noxafil Suspension; they may also decrease Noxafil Suspension's effectiveness
• 5-HT₁ receptor agonists (eg, eletriptan), aldosterone blockers (eg, eplerenone), benzodiazepines (eg, midazolam, alprazolam), buspirone, calcium channel blockers (eg, nifedipine), cinacalcet, conivaptan, cyclophosphamide, cyclosporine, digoxin, ergot alkaloids (eg, ergotamine, dihydroergotamine), erlotinib, eszopiclone, gefitinib, HIV protease inhibitors (eg, ritonavir), muscarinic receptor antagonists (eg, tolterodine), narcotic pain medicines (eg, fentanyl), phosphodiesterase inhibitors (eg, sildenafil), quinazolines (eg, alfuzosin), ranolazine, sirolimus, sulfonylureas (eg, glipizide), tacrolimus, tyrosine kinase receptor inhibitors (eg, dasatinib), or vinca alkaloids (eg, vincristine) because the risk of their side effects may be increased by Noxafil Suspension
• Hormonal contraceptives (eg, birth control pills) because their effectiveness may be decreased by Noxafil Suspension

How to use Noxafil Suspension:

Use Noxafil Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Noxafil Suspension by mouth with food.
• Shake well before each use.
• Use the measuring spoon marked for medicine dosing that comes with Noxafil Suspension. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Rinse the measuring spoon with water after each use and before storage.
• Take Noxafil Suspension on a regular schedule to get the most benefit from it.
• Taking Noxafil Suspension at the same time each day will help you remember to take it.
• Continue to take Noxafil Suspension even if you feel well. Do not miss any doses.
• If you miss a dose of Noxafil Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Important safety information:

• Noxafil Suspension may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Noxafil Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Contact your doctor if you experience severe diarrhea or vomiting. The effectiveness of Noxafil Suspension may be decreased.
• Noxafil Suspension only works against fungi; it does not treat viral infections (eg, the common cold) or bacterial infections.
• Be sure to use Noxafil Suspension for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Long-term or repeated use of Noxafil Suspension may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Hormonal birth control (eg, birth control pills) may not work as well while you are using Noxafil Suspension. To prevent pregnancy, use an extra form of birth control (eg, condoms).
• Diabetes patients - Noxafil Suspension may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Lab tests, including liver function and heart function tests, may be performed while you use Noxafil Suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Noxafil Suspension should be used with extreme caution in CHILDREN younger than 13 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: It is not known if Noxafil Suspension can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Noxafil Suspension while you are pregnant. It is not known if Noxafil Suspension is found in breast milk. If you are or will be breast-feeding while you use Noxafil Suspension, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Noxafil Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; coughing; diarrhea; dizziness; headache; muscle, joint, or back pain; nausea; sore throat; stomach pain or upset; tiredness; trouble sleeping.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or tightness; dark urine; fast or irregular heartbeat; fever, chills, or persistent sore throat; loss of appetite; mouth inflammation; pale stools; severe or persistent headache or dizziness; severe or persistent nausea, vomiting, diarrhea, or stomach pain; severe or persistent tiredness or weakness; shortness of breath; swelling of the ankles, feet, or hands; tremor; unusual bruising or bleeding; vaginal bleeding; yellowing of the skin or eyes.