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Niaspan 500mg ER Tablets
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Niaspan Controlled-Release Tablets are used for:

Improving cholesterol levels, reducing the risk for a second heart attack, slowing or treating hardening of the arteries, and lowering very high serum triglyceride levels. Niaspan is used in combination with diet. Niaspan may be used alone or with other medicines. Niaspan may also be used for other conditions as determined by your doctor.

Niaspan Controlled-Release Tablets are an antihyperlipidemic. Niaspan works by reducing low-density lipoprotein ("bad") cholesterol and triglycerides and increasing high-density lipoprotein ("good") cholesterol.

Do NOT use Niaspan Controlled-Release Tablets if:

  • you are allergic to any ingredient in Niaspan Controlled-Release Tablets
  • you have severe or unexplained liver problems, an active peptic ulcer, or a history of arterial bleeding

Before using Niaspan Controlled-Release Tablets:

Some medical conditions may interact with Niaspan Controlled-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of chest pain, diabetes, gallbladder problems, glaucoma, gout, heart problems or a recent heart attack, kidney or liver problems, low blood pressure, low phosphate levels, muscle problems (eg, rhabdomyolysis), stomach problems (eg, peptic ulcers), or thyroid problems
  • if you have a history of bleeding problems or are taking anticoagulants (eg, warfarin)
  • if you consume large amounts of alcohol

Some MEDICINES MAY INTERACT with Niaspan Controlled-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin) because side effects such as bleeding may occur
  • Fibrates (eg, gemfibrozil, fenofibrate) or HMG-CoA reductase inhibitors ("statins") (eg, simvastatin) because side effects, such as muscle aches and weakness that may be a symptom of a serious medical condition called rhabdomyolysis, may occur
  • Medicine for high blood pressure (eg, clonidine, prazosin) because side effects, such as dizziness and very low blood pressure, may occur
  • Alcohol because toxic effects, such as delirium and lactic acidosis, may occur

How to use Niaspan Controlled-Release Tablets:

Use Niaspan Controlled-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • To minimize flushing and upset stomach, take Niaspan Controlled-Release Tablets at bedtime after a low-fat snack (eg, low-fat yogurt, banana, crackers with a glass of milk) unless your doctor directs otherwise. Do not take Niaspan Controlled-Release Tablets with alcohol, a hot drink, or spicy foods.
  • Do not take bile acid sequestrants (eg, colestipol, cholestyramine) within 4 to 6 hours of taking Niaspan Controlled-Release Tablets.
  • Swallow Niaspan Controlled-Release Tablets whole. Do not break, crush, or chew before swallowing.
  • If you miss a dose of Niaspan Controlled-Release Tablets and you are taking 1 dose daily at bedtime, skip the missed dose. Do not take the dose in the morning or 2 doses at once. If you miss several doses, contact your doctor.

Important safety information:

  • Niaspan Controlled-Release Tablets may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Niaspan Controlled-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Niaspan Controlled-Release Tablets may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect. To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • Niaspan Controlled-Release Tablets may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Do not substitute Niaspan Controlled-Release Tablets for any other type of niacin without talking with your doctor. Severe liver damage can occur.
  • If you stop taking Niaspan Controlled-Release Tablets for an extended period, contact your doctor before you start taking it again. Your dose may need to be adjusted.
  • Follow the diet and exercise program given to you by your health care provider.
  • Flushing occurs with Niaspan Controlled-Release Tablets and may last for several hours. Talk with your doctor if flushing becomes bothersome. Take Niaspan Controlled-Release Tablets at bedtime so that flushing will occur during sleep. If you are awakened by flushing at night, get up slowly, especially if you feel dizzy or faint or if you are taking blood thinners. Take aspirin or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen) 30 minutes before taking Niaspan Controlled-Release Tablets to lessen flushing.
  • Diabetes patients - Niaspan Controlled-Release Tablets may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine
  • Diabetes patients - Niaspan Controlled-Release Tablets may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Do not take large doses of vitamins while you use Niaspan Controlled-Release Tablets unless your doctor tells you to.
  • Report any unexplained muscle pain, tenderness, or weakness to your doctor right away, especially if you also have a fever or general body discomfort.
  • Niaspan Controlled-Release Tablets may interfere with certain lab tests, including plasma or urinary catecholamine tests or urine glucose tests. Be sure your doctor and lab personnel know you are taking Niaspan Controlled-Release Tablets.
  • Lab tests, including liver function tests, blood glucose, and serum creatine kinase tests, may be performed while you use Niaspan Controlled-Release Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Niaspan Controlled-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects.
  • Niaspan Controlled-Release Tablets should be used with extreme caution in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Niaspan Controlled-Release Tablets while you are pregnant. Niaspan Controlled-Release Tablets are found in breast milk. Do not breast-feed while taking Niaspan Controlled-Release Tablets.

Possible side effects of Niaspan Controlled-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; heartburn; increased cough, indigestion, or upset stomach; nausea; temporary skin redness, itching, tingling, or feelings of warmth (flushing); vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); black, tarry, or bloody stools; changes in vision (eg, cloudy or blurred vision); decrease in urine or dark-colored urine; fainting; fast or irregular heartbeat; flu-like symptoms (eg, chills, fever, persistent sore throat); increased sweating; loss of appetite; muscle pain, tenderness, swelling, or weakness (with or without fever and fatigue); numbness or persistent tingling of the skin; severe dizziness or headache; severe or persistent diarrhea, nausea, or vomiting; shortness of breath; stomach pain; swelling of the hands, legs, or feet; unusual bruising or bleeding; vomit that looks like coffee grounds; yellowing of the skin or eyes.

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