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Chemical Name: SITAGLIPTIN (si-ta-GLIP-tin) and METFORMIN (met-FOR-min)
This medicine is a dipeptidyl peptidase-4 enzyme inhibitor and biguanide antidiabetic combination used along with a diet and exercise program to control high blood sugar in certain patients with type 2 diabetes.
WARNING: THIS MEDICINE MAY RARELY CAUSE A SERIOUS AND SOMETIMES FATAL CONDITION CALLED LACTIC ACIDOSIS. The risk of lactic acidosis may be greater if you have liver problems, kidney problems, or heart failure. The risk may also be greater in patients who are elderly or who drink alcohol. DO NOT BEGIN TO TAKE THIS MEDICINE IF YOU ARE MORE THAN 80 YEARS OLD UNLESS LAB TESTS SHOW THAT YOU DO NOT HAVE DECREASED KIDNEY FUNCTION. CONTACT YOUR DOCTOR RIGHT AWAY IF YOU NOTICE SYMPTOMS SUCH AS muscle pain or tenderness, unusual drowsiness, dizziness or lightheadedness, slow or irregular heartbeat, fast or difficult breathing, unusual stomach discomfort, unusual weakness or tiredness, feeling of being unusually cold, or general feeling of being unwell. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking amiloride; beta-blockers (such as propranolol); cimetidine; digoxin; morphine; procainamide; quinidine; quinine; ranitidine; triamterene; trimethoprim; vancomycin; calcium channel blockers (such as nifedipine); corticosteroids (such as prednisone); diuretics (such as furosemide, hydrochlorothiazide); estrogen; hormonal contraceptives (such as birth control pills); insulin; isoniazid; nicotinic acid; phenothiazines (such as chlorpromazine); phenytoin; sulfonylureas (such as glipizide); sympathomimetics (such as albuterol, pseudoephedrine); or thyroid hormones (such as levothyroxine). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor if you drink alcohol or have a history of heart problems (such as heart failure), lung or breathing problems, thyroid problems, stomach or bowel problems (such as paralysis, blockage), adrenal or pituitary problems, lactic acidosis, or alcohol abuse. Inform your doctor of any other medical conditions including vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B12 levels, anemia, dehydration, infection, fever, recent injury, moderate to severe burns, upcoming surgery or certain lab procedures, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have type 1 diabetes, congestive heart failure that is treated by medicine, a severe infection, low blood oxygen levels, kidney or liver problems, high blood ketone or acid levels (such as diabetic ketoacidosis), severe dehydration, previous stroke, a recent heart attack, or if you are in shock. USE OF THIS MEDICINE IS NOT RECOMMENDED if you will be having surgery or certain lab procedures, or if you are 80 years old or more and have not had a kidney function test. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
Follow the directions for using this medicine provided by your doctor. This medicine may come with a patient information leaflet. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. TAKE THIS MEDICINE with food. DRINK PLENTY OF FLUIDS while taking this medicine. STORE THIS MEDICINE at room temperature between 68 and 77 degrees F (20 and 25 degrees C), in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Take this medicine regularly to receive the most benefit from it. Taking this medicine at the same times each day will help you to remember. CONTINUE TO TAKE THIS MEDICINE even if you feel well. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.
DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. FOLLOW THE DIET AND EXERCISE PLAN provided by your doctor. DIZZINESS MAY OCCUR WHILE YOU ARE USING THIS MEDICINE. This effect may be worse if you take it with alcohol or certain medicines. Use this medicine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. THIS MEDICINE MAY COMMONLY CAUSE STOMACH UPSET, INDIGESTION, NAUSEA, VOMITING, OR DIARRHEA AT THE BEGINNING OF TREATMENT. If you develop unusual or unexpected stomach problems, or if you develop stomach problems later during treatment, contact your doctor at once. This may be a sign of lactic acidosis. IF VOMITING OR DIARRHEA OCCURS, you will need to take care not to become dehydrated. Contact your doctor for instructions. THIS MEDICINE DOES NOT USUALLY LOWER BLOOD SUGAR LEVELS. Low blood sugar may be more likely to occur if you skip a meal, exercise heavily, or drink alcohol. It may also be more likely if you take this medicine along with certain other medicines for diabetes (eg, sulfonylureas, insulin). It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you do not have a reliable source of glucose available, eat a quick source of sugar such as table sugar, honey, or candy, or drink a glass of orange juice or non-diet soda to quickly raise your blood sugar level. TELL YOUR DOCTOR IMMEDIATELY about the reaction. To prevent hypoglycemia, eat meals on a regular schedule and do not skip meals. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine. Laboratory and/or medical tests such as kidney function tests, fasting blood glucose, hemoglobin A1C, or blood counts, should be done to monitor your progress or to check for side effects. IF YOUR BLOOD SUGARS HAVE BEEN UNDER CONTROL AND ARE SUDDENLY DIFFICULT TO MANAGE, contact your doctor as soon as possible. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, LABORATORY TESTS, OR SURGERY, tell the doctor or dentist that you are using this medicine. During times of stress such as fever, infection, injury, or surgery, it may be more difficult to control your blood sugar. Consult your doctor, as a change in your medicine may be required. DO NOT drink large amounts of alcohol while you are taking this medicine. TALK TO YOUR DOCTOR OR HEALTHCARE PROVIDER BEFORE YOU DRINK ALCOHOL while you use this medicine. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of the medicine. Low blood sugar levels may be more difficult to recognize in the elderly. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED in breast milk. DO NOT BREAST-FEED while taking this medicine.
SIDE EFFECTS that may occur while taking this medicine include diarrhea, gas, headache, indigestion, nausea, sore throat, stomach pain or upset, stuffy or runny nose, vomiting, or weakness. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience chest pain or discomfort; dizziness or lightheadedness; fast or difficult breathing; fever, chills, or persistent sore throat; feeling of being unusually cold; general feeling of being unwell; muscle pain or weakness; slow or irregular heartbeat; unusual or persistent stomach pain or discomfort; unusual drowsiness; unusual tiredness or weakness. An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include rapid or trouble breathing, severe drowsiness, and slow or irregular heartbeat.
This medicine is not a substitute for proper diet and regular exercise. It is recommended you attend a diabetes education program to better understand diabetes, prevention of complications, and all the important aspects of its treatment. These include meals/diet, exercise, weight loss, personal hygiene, medicine and blood glucose monitoring, and the need for regular eye, foot, and medical exams. Follow your doctor's instructions carefully. Carry an identification card at all times that says you are diabetic. Monitor your blood sugar levels regularly according to your doctor's directions. If your blood sugar level is often higher or lower than it should be and you are taking this medicine according to directions, check with your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. KEEP THIS MEDICINE out of the reach of children and pets. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.
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