Tablets
Chemical Name: ERGOTAMINE (er-GOT-a-meen) and CAFFEINE (kaf-EEN)

Common uses
This medicine is an ergot alkaloid and analgesic aid combination used to prevent and treat migraine headaches. It may also be used to treat other conditions as determined by your doctor.

Before using
WARNING: Infrequently, a very serious life-threatening decrease in the amount of blood supply to the hands and feet (peripheral ischemia) and rarely to the brain can occur when this medication is taken with drugs that affect liver metabolism (e.g., potent CYP 3A4 enzyme inhibitors). Do not take this medicine with macrolide antibiotics (e.g., erythromycin, clarithromycin, troleandomycin), protease inhibitors (e.g., ritonavir, nelfinavir, indinavir, amprenavir, saquinavir), azole antifungals (e.g., ketoconazole, itraconazole). Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking telithromycin, delavirdine, efavirenz, voriconazole, sibutramine, dexfenfluramine, fenfluramine, "triptan" migraine drugs (e.g., sumatriptan). Also see WARNING statement above. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking dopamine, nitrates (e.g., isosorbide, nitroglycerin), nefazodone, fluconazole, fluoxetine, fluvoxamine, zileuton, metronidazole, clotrimazole, beta-blockers (e.g., propranolol), nicotine (e.g., tobacco, nicotine patches), caffeine, theophylline, or other mild CYP 3A4 enzyme inhibitors. Consult your pharmacist for more information. Inform your doctor of any other medical conditions including smoking/tobacco use, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of high blood pressure or heart or kidney conditions. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.

Directions
Follow the directions for using this medicine provided by your doctor. BEGIN USING THIS MEDICINE at the first sign of an attack. DO NOT TAKE MORE THAN 6 TABLETS for any headache or 10 tablets in 1 week, unless otherwise directed by your doctor. Do not use daily on a regular basis. AVOID EATING GRAPEFRUIT OR DRINKING GRAPEFRUIT JUICE WHILE TAKING THIS MEDICINE. STORE THIS MEDICINE at room temperature in a tightly-closed container, away from heat and light.

Cautions
IF YOUR SYMPTOMS DO NOT IMPROVE or if they become worse, check with your doctor. AVOID LARGE AMOUNTS OF caffeine-containing foods and beverages, such as coffee, tea, cocoa, cola drinks, and chocolate. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. FOR WOMEN: DO NOT USE THIS MEDICINE if you are pregnant. IF YOU SUSPECT THAT YOU COULD BE PREGNANT, contact your doctor immediately. THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine.

Possible side effects
SIDE EFFECTS, that may go away during treatment, include nausea, vomiting, weakness of the legs, or arm or leg pain. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience numbness or tingling of your fingers or toes, chest pain, change in heart rate, bluish discoloration of the fingers and toes, or itching. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Drug interactions
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other.

If you take too much
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea; diarrhea; vomiting; numbness, tingling, and bluish discoloration of fingers and toes; drowsiness; and seizures.

Additional information
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.