What is AccuNeb�?

AccuNeb� is a medicine that is used for the relief of bronchospasms caused by asthma in children ages 2 to 12 years. Bronchospasm is the tightening and swelling of the muscles around the airways. AccuNeb� can help relax these airway muscles for up to 6 hours so that your child may breathe more easily.

Who should not use AccuNeb�?

Do not give your child AccuNeb� if he or she is allergic to any of its ingredients. The active ingredient is albuterol sulfate. See the end of this leaflet for a complete list of ingredients.

What should I tell my child�s doctor before giving AccuNeb�?

Tell your child�s doctor about all of your child�s medical conditions including if your child has:

� Heart problems

� High blood pressure

� Seizures

� A thyroid problem called hyperthyroidism

� Diabetes

Tell your child�s doctor about all the medicines your child takes, including prescription and nonprescription medicines, vitamins and herbal supplements. AccuNeb� and some other medicines can affect each other and may cause serious side effects. Especially tell your child�s doctor if your child is taking or using:

� Any short-acting bronchodilator medicines (sometimes called rescue inhalers)

� Epinephrine

� Medicines called monoamine oxidase inhibitors (MAOIs) or tricyclic anti-depressants or has stopped taking them in the past 2 weeks. These medicines are usually used for mental problems.

� Medicines called beta-blockers (used for heart problems and high blood pressure)

� Certain diuretic medicines (water pills)

� Digoxin

Know the medicines your child takes. Keep a list of them and show it to your child�s doctor and pharmacist each time your child gets a new medicine.

How should AccuNeb� be given?

Read the Patient�s Instructions for Use that comes with AccuNeb�. Ask your pharmacist for these instructions if they are not with your medicine. Keep the instructions with AccuNeb� because you may want to read them again.

� Give AccuNeb� exactly as prescribed for your child. Do not change your child�s dose or how often it is used without talking to your child�s doctor first.

� AccuNeb� is breathed into the lungs. AccuNeb� is used with a special breathing machine called a nebulizer. Do not mix other medicines with AccuNeb� in the nebulizer. Do not use AccuNeb� that is not clear and colorless.

� Call your child�s doctor or get emergency help right away if your child�s breathing is not helped or gets worse during treatment with AccuNeb�.

� Call your child�s doctor right away if your child needs to use AccuNeb� more often than prescribed.

� AccuNeb� has not been studied for treating acute attacks of bronchospasm (rescue use). Your child may need a different medicine for rescue use.

� If you give your child too much AccuNeb�, call your child�s doctor right away.

What are the side effects with AccuNeb�?

AccuNeb� may cause the following serious side effects:

Worsening of the tightening and swelling of the muscles around your child�s airways (bronchospasm). This side effect can be life threatening. Call your child�s doctor or get emergency help right away if your child�s breathing is not helped or gets worse during treatment with AccuNeb�.

Serious and life threatening allergic reactions. Symptoms of a serious allergic reaction include:

� Hives, rash

� Swelling of your child�s face, eyelids, lips, tongue, or throat, and trouble swallowing

� Worsening of your child�s breathing problems such as wheezing, chest tightness or shortness of breath

� Shock (loss of blood pressure and consciousness).

The most common side effects with AccuNeb� include a fast or irregular heartbeat, chest pain, shakiness, or nervousness.

How should AccuNeb� be stored?

� Store AccuNeb� at room temperature, 36� to 77�F (2� to 25�C) in its tightly closed container.

� Protect vials from light before use. Therefore, keep unused vials in the foil pouch or carton. Once removed from the foil pouch, use vial(s) within one week.

� Do not use AccuNeb� after the expiration (EXP) date printed on the vial. Do not use AccuNeb� that is not clear and colorless.

� Safely, discard AccuNeb� that is out-of-date or no longer needed.

� Keep AccuNeb� and all medicines out of the reach of children.

General Information about AccuNeb�

Medicines are sometimes prescribed for conditions that are not mentioned in the patient information leaflets. Do not use AccuNeb� for a condition for which it was not prescribed. Do not give AccuNeb� to other people, even if they have the same symptoms your child has. It may harm them.